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Collection:
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NASA Marshall Space Flight Center Collection
Collection
NASA Marshall Space Flight Center Collection
Collection
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Name of Image:
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Cultured Human Renal Cortical Cells
Name_of_Image
Cultured Human Renal Cortical Cells
Name of Image
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Full Description:
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During the STS-90 shuttle flight in April 1998, cultured renal cortical cells revealed new information about genes. Timothy Hammond, an investigator in NASA's microgravity biotechnology program was interested in culturing kidney tissue to study the expression of proteins useful in the treatment of kidney diseases. Protein expression is linked to the level of differentiation of the kidney cells, and Hammond had difficulty maintaining differentiated cells in vitro. Intrigued by the improvement in cell differentiation that he observed in rat renal cells cultured in NASA's rotating wall vessel (a bioreactor that simulates some aspects of microgravity) and during an experiment performed on the Russian Space Station Mir, Hammond decided to sleuth out which genes were responsible for controlling differentiation of kidney cells. To do this, he compared the gene activity of human renal cells in a variety of gravitational environments, including the microgravity of the space shuttle and the high-gravity environment of a centrifuge. Hammond found that 1,632 genes out of 10,000 analyzed changed their activity level in microgravity, more than in any of the other environments. These results have important implications for kidney research as well as for understanding the basic mechanism for controlling cell differentiation.
Full_Description
During the STS-90 shuttle flight in April 1998, cultured renal cortical cells revealed new information about genes. Timothy Hammond, an investigator in NASA's microgravity biotechnology program was interested in culturing kidney tissue to study the expression of proteins useful in the treatment of kidney diseases. Protein expression is linked to the level of differentiation of the kidney cells, and Hammond had difficulty maintaining differentiated cells in vitro. Intrigued by the improvement in cell differentiation that he observed in rat renal cells cultured in NASA's rotating wall vessel (a bioreactor that simulates some aspects of microgravity) and during an experiment performed on the Russian Space Station Mir, Hammond decided to sleuth out which genes were responsible for controlling differentiation of kidney cells. To do this, he compared the gene activity of human renal cells in a variety of gravitational environments, including the microgravity of the space shuttle and the high-gravity environment of a centrifuge. Hammond found that 1,632 genes out of 10,000 analyzed changed their activity level in microgravity, more than in any of the other environments. These results have important implications for kidney research as well as for understanding the basic mechanism for controlling cell differentiation.
Full Description
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Date of Image:
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1998-04-01
Date_of_Image
1998-04-01
Date of Image
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Category:
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Microgravity
Category
Microgravity
Category
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(MRPO) MRD-SPD Discipline(s):
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Biotechnology
(MRPO)_MRD-SPD_Disci pline(s)
Biotechnology
(MRPO) MRD-SPD Discipline(s)
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(MRPO) Subject Type:
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Science
(MRPO)_Subject_Type
Science
(MRPO) Subject Type
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term:
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gene bioreactor STS-90 Timothy Hammond renal cortical cells protein expression Mir kidney research
Keywords
gene bioreactor STS-90 Timothy Hammond renal cortical cells protein expression Mir kidney research
term
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facet_what:
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RAT
facet_what
RAT
facet_what
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facet_what:
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Space Shuttle Orbiter
facet_what
Space Shuttle Orbiter
facet_what
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facet_what:
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Russian Mir Space Station
facet_what
Russian Mir Space Station
facet_what
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facet_where:
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Marshall Space Flight Center (MSFC)
facet_where
Marshall Space Flight Center (MSFC)
facet_where
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facet_when:
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April 1998
facet_when
April 1998
facet_when
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facet_when_year:
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1998
facet_when_year
1998
facet_when_year
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Reference Number:
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MSFC-75-SA-4105-2C
Reference_Number
MSFC-75-SA-4105-2C
Reference Number
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MIX #:
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0000564
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NIX #:
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MSFC-0000564
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MSFC Negative Number:
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0000564
MSFC_Negative_Number
0000564
MSFC Negative Number
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UID:
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SPD-MARSH-0000564
UID
SPD-MARSH-0000564
UID
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original url:
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original_url
original url
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